Dihydrocyclosporin A

CAS No. 59865-15-5

Dihydrocyclosporin A ( Dihydrocyclosporin-A;Dihydrocyclosporin A )

Catalog No. M27974 CAS No. 59865-15-5

Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 288 Get Quote
10MG 423 Get Quote
25MG 695 Get Quote
50MG 972 Get Quote
100MG 1314 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Dihydrocyclosporin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.
  • Description
    Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.(In Vitro):Dihydrocyclosporin A was able to inhibit the proliferation of L. donovani promastigotes (IC50: 21.24 μM and 12.14 μM at 24 h and 48 h, respectively) and intracellular amastigotes (IC50: 5.23 μM and 4.84 μM at 24 and 48 h, respectively) in vitro. Dihydrocyclosporin A caused several alterations in the morphology and ultrastructure of L. donovani, especially in the mitochondria. However, Dihydrocyclosporin A showed high cytotoxicity towards cells of the mouse macrophage cell line RAW264.7, with CC50 values of 7.98 μM (24 h) and 6.65 μM (48 h).
  • Synonyms
    Dihydrocyclosporin-A;Dihydrocyclosporin A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α1B-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    59865-15-5
  • Formula Weight
    1204.7
  • Molecular Formula
    C62H113N11O12
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@@]1([C@H](O)[C@H](C)CCCC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)C(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sironi G, et al. Effects of intracavernous administration of selective antagonists of alpha(1)-adrenoceptor subtypes on erection in anesthetized rats and dogs. J Pharmacol Exp Ther. 2000 Mar;292(3):974-81.
molnova catalog
related products
  • Benzydamine

    Benzydamine is a benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects.?Benzydamine is used to reduce post-surgical and post-traumatic pain and edema and to promote healing.

  • NPC 15199

    NPC 15199 is an anti-inflammatory agent.NPC-15199 [(N-(9-fluorenylmethoxycarbonyl)L-leucine)], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer (BFTC) cells.?

  • Cetylpyridinium chlo...

    Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound used in some types of mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays.