Dihydrocyclosporin A

CAS No. 59865-15-5

Dihydrocyclosporin A ( Dihydrocyclosporin-A;Dihydrocyclosporin A )

Catalog No. M27974 CAS No. 59865-15-5

Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 288 Get Quote
10MG 423 Get Quote
25MG 695 Get Quote
50MG 972 Get Quote
100MG 1314 Get Quote
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Biological Information

  • Product Name
    Dihydrocyclosporin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.
  • Description
    Dihydrocyclosporin A is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.(In Vitro):Dihydrocyclosporin A was able to inhibit the proliferation of L. donovani promastigotes (IC50: 21.24 μM and 12.14 μM at 24 h and 48 h, respectively) and intracellular amastigotes (IC50: 5.23 μM and 4.84 μM at 24 and 48 h, respectively) in vitro. Dihydrocyclosporin A caused several alterations in the morphology and ultrastructure of L. donovani, especially in the mitochondria. However, Dihydrocyclosporin A showed high cytotoxicity towards cells of the mouse macrophage cell line RAW264.7, with CC50 values of 7.98 μM (24 h) and 6.65 μM (48 h).
  • Synonyms
    Dihydrocyclosporin-A;Dihydrocyclosporin A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α1B-adrenergic receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    59865-15-5
  • Formula Weight
    1204.7
  • Molecular Formula
    C62H113N11O12
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@@]1([C@H](O)[C@H](C)CCCC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)C(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sironi G, et al. Effects of intracavernous administration of selective antagonists of alpha(1)-adrenoceptor subtypes on erection in anesthetized rats and dogs. J Pharmacol Exp Ther. 2000 Mar;292(3):974-81.
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